In Brief
A team of Physicians at the University of Pennsylvania's School of Medicine now has their project of modifying the immune cells of 18 different cancer patients with the CRISPR-Cas9 system approved by the National Institute of Health.

Hello Cancer, meet CRISPR

CRISPR is the gift that keeps on giving—when it’s not fighting blindness, tackling HIV, or even recording real-time immune responses, it is taking on the emperor of all maladies: cancer.

T- Cell(Blue) and Cancer Cell (Red) Credit:STEVE GSCHMEISSNER/SPL
T-cell(Blue) and Cancer cell (Red) Credit:STEVE GSCHMEISSNER/SPL

But what’s even more fascinating about this use of CRISPR is that the National Institute of Health’s (NIH) Recombinant DNA Research Advisory Committee (RAC) has approved the first-ever use of CRISPR in human cancer therapy, a monumental step in the history of the gene-editing technology.

While receiving funding from the Parker Immunotherapy Foundation, physicians at the University of Pennsylvania School of Medicine plan on working with the T-cells of 18 patients who have either melanoma, sarcoma, or myeloma by performing three distinct CRISPR edits:

  1. Offensive: T-cells will be modified to have a gene that produces a protein that will help T-cells identify and target cancer cells.
  2. Removal:  T-cells will be modified so that they do not have a protein that is theorized to inhibit cancer cell identification and targeting.
  3. Defensive: T-cells will have a gene removed, so that they will no longer produce a certain protein that identifies them as Immune T-cells, thereby preventing cancer cells from inhibiting them.

An Approval to Remember

You may be scratching your head, thinking that approving this experimental therapy is a “no-brainer,” but human gene therapy trials have been bumpy since 1999.

The story of Jesse Gelsinger echoes far too loudly with this team of physicians in particular—as Gelsinger was only 18 when he passed away in a University of Pennsylvania experimental gene therapy study. It was later discovered that members of the research initiative had hidden detrimental data from previous animal experiments as there was a financial stake involved in the success of the trial.

While a member of the current team is believed to hold ties to Novartis, a pharmaceutical company that owns several T-cell technology patents, the scientific community is watching closely, and ensuring all precautions are taken.

Here’s to a better tomorrow thanks to CRISPR.