New research from a team at MIT indicates symptoms of Alzheimer’s disease (AD) affecting patient’s memories may be reversible. AD causes memory loss by setting up genetic “blockades” formed when the enzyme HCAC2 condenses the genes of the brain responsible for memory. Eventually, those genes become useless; unexpressed, the genes are unable to cause the formation of new memories or retrieval of existing ones.
Clearly, blocking HCAC2 in the brain is an obvious fix; however, it has to date been impossible, in that all prior attempts have negatively affected the internal organs which require other enzymes in the histone deacetylase (HDAC) family for normal function. Researchers at MIT have now found something they hope might be the answer: LED lights which they use to prevent HCAC2 alone from binding with Sp3, its genetic blockade formation partner in crime (and Alzheimer’s).
“This is exciting because for the first time we have found a specific mechanism by which HDAC2 regulates synaptic gene expression,” Director of MIT’s Picower Institute for Learning and study lead author Li-Huei Tsai explained to MIT News. “If we can remove the blockade by inhibiting HDAC2 activity or reducing HDAC2 levels, then we can restore expression of all these genes necessary for learning and memory.”
This AD research is in the early stages yet, having only been conducted with mice. No usable remedy for humans will be forthcoming for some time, but even so, this is one of the most promising semblances of a cure for Alzheimer’s to date, with the potential to help more than 5.5 million Americans and almost 44 million worldwide.