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Hard Science

Some Alzheimer’s Patients Seem to be “Resistant” to Memory Loss

Brains with all of the signs of the disease, yet none of the symptoms.

A New Lead

Alzheimer’s disease is a devastating form of dementia that afflicts one in nine Americans over the age of 65. Symptoms include memory loss and movement difficulty. One of the clearest signs of the disease is the presence of amyloid plaques and neurofibrillary tangles on the brains of patients.

Credit:NIH-NIA
Credit:NIH-NIA

Researchers from Northwestern University conducted a study which suggests there are those who exhibit normal to superior memory and brain function in their elderly years while still having developed those signature signs of the disease.

Neurologist Changiz Geula and his team picked eight elderly participants above 90 years old who showed great cognitive ability and memory capacity. After these participants passed away, the researchers examined their brains and they found that while 5 out of the 8 brains looked normal, 3 showed the tangles and plaques around the regions of the brain that are connected to memory, speech, and emotion.

In addition to this, the researchers also found that the nerves from the hippocampus, or the part of the brain tasked with memory formation, were still intact for those 3 people who showed signs of Alzheimer’s. “These findings point to mechanisms in some elderly that protect their brains against the toxic effects of plaques and tangles normally associated with dementia,” says Geula.

Protection For Alzheimer’s?

However, there are some limitations to this study, as it is not yet peer-reviewed, the sample size used is also quite low. Therefore, at this stage in the research, it may be wise to view these results with a healthy dose of skepticism.

Geula and his team do plan on conducting the study with a much larger sample size in addition to finding out how the 3 elderly participants were able to resist showing Alzheimer’s symptoms. In an interview with The Telegraph, he says, “We will look at genetic, dietary and environmental influences that could confer protection for neurons against Alzheimer’s pathology.”

The study of these mechanisms could eventually lead to better treatment for people afflicted with Alzheimer’s Disease and other ways to improve on the cognitive health of the elderly.

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