• He argued there were "serious and unquantifiable safety issues", big ethical questions and no compelling medical reason to do it.
  • Dr Collins, a key player in the Human Genome Project, released a statement saying “advances in technology have given us an elegant new way of carrying out genome editing, but the strong arguments against engaging in this activity remain. These include the serious and unquantifiable safety issues, ethical issues presented by altering the germline in a way that affects the next generation without their consent."
  • Last week a team at Sun Yat-sen University, in Guangzhou, reported using Crispr to modify defective parts of DNA that lead to a blood disorder called beta thalassaemia. However, there were a number of other "off-target" mutations introduced to the genetic code.

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