Allan Henderson
Early Man

Scientists Grow Petri Dish Mini-Brains With Neanderthal DNA

byVictor Tangermann
6. 18. 20
Allan Henderson

"We were curious how much of the Neanderthal genome could be explored if you just have access to stem cells from the right people."

Neanderthal Mini-Brains

To study how early humans related to the ancient human subspecies known as Neanderthals, CNN reports, a team of European scientists grew mini-brains from human stem cells that contain Neanderthal DNA and proteins.

“We were curious how much of the Neanderthal genome could be explored if you just have access to stem cells from the right people,” Grayson Camp, lead author of a new study published in the journal Stem Cell Reports today and genomics PhD at the Institute of Molecular and Clinical Ophthalmology in Switzerland, told CNN.

DNA Similarities

The team analyzed genomes from individuals with Northern European descent and compared them to a reference Neanderthal genome created in 2010 by geneticist Svante Pääbo “to figure out which parts were likely derived from Neanderthals and which parts were not,” according to Camp.

“Per individual, there’s something like between 1 percent and 4 percent of the genome likely derived from Neanderthals,” he added.

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Brain Blobs

From there, the team grew three-dimensional blobs of brain tissue inside a petri dish. These tiny brains, also called organoids, are often used to test the effects of drugs.

They are specifically not “lab-grown Neanderthal brains,” as Camp assured CNN. “These are human cells, they’re not Neanderthal cells but human cells that have Neanderthal DNA naturally inside them,” Camp said.

The research also could give us insight into the early diet of Neanderthals, he said, and how their traits shaped human ones over thousands of years.

READ MORE: Scientists have grown mini brains containing Neanderthal DNA [CNN]

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More on Neanderthals: Lab-Grown Neanderthal Minibrains Reveal How They’re Different From Humans’


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