- The researchers describe using an experimental approach previously used to build bioartificial organs to engineer rat forelimbs with functioning vascular and muscle tissue. They also provided evidence that the same approach could be applied to the limbs of primates.
- Limbs contain muscles, bone, cartilage, blood vessels, tendons, ligaments and nerves - each of which has to be rebuilt and requires a supporting structure called the matrix. This shows that the matrix of all of these tissues can be maintained in their natural relationship to each other, that they can culture the entire construct over prolonged periods, and that they can repopulate the vascular system and musculature.
- Additional next steps will be replicating our success in muscle regeneration with human cells and expanding that to other tissue types, such as bone, cartilage and connective tissue.
Team develops transplantable bioengineered forelimb in an animal model
6. 3. 15 by Alex Klokus