• The findings could lead to personalised medicine that ‘reads’ a cancer patient’s DNA and only attacks defective cells – in contrast to the scattergun approach of conventional chemotherapy, which attacks all dividing cells, including healthy ones.
  • By using cutting edge computing techniques, the team have been able to examine much larger data sets than ever before. Dr Pearl said: “This analysis shows that there are many other cancers where new targeted drugs could selectively kill tumours with DNA repair defects.
  • Using ‘big data’ analysis, our study has identified untargeted DNA repair proteins that look especially promising as the targets for new anti-cancer drugs. Such drugs would not only prove useful in their own right, but also potentially in combination with radiotherapy or other drugs to overcome treatment resistance. They hope this study will help speed up the development of new personalised cancer treatments.

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