• They coated plastic (polystyrene or polyacrylamide) microparticles with 40 base pairs of DNA, forming gel-like materials that they could extrude from a 3D printer* to form solid shapes (up to centimeters in size). These were used as scaffolds to host growing cells within the matrix.
  • The researchers have demonstrated multicellular colonies of living cells growing in this colloidal gel. “More advanced DNA computation might also allow us to algorithmically determine the assembly process at the nano- to microscales,” the authors explain. “DNA circuits could mediate the conditional or algorithmic assembly of DNA-modified subunits into higher-order morphologies.
  • Such processes have previously been demonstrated at the nanoscale with subunits such as DNA origami tiles, and these methods provide a potential for further scaling.

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