- Safety tests on three people, published in the journal Science, showed the immune system could be trained to fight skin cancers. The American team say the early results mark a "significant step" towards personalised cancer vaccines.
- The team, mainly based in St Louis and Oklahoma City, analysed the genetic mutations to predict the new and unique flags that would be flown by the cancer cells. A computer algorithm then analysed the new flags, known as neoantigens, to decide which would be the best targets for a vaccine.
- Personalised vaccines were given to three patients with advanced tumours in 2013. One was in remission and has stayed cancer-free; another still has stable tumours; and the third patient's tumour shrank in the months after the vaccine before returning to its original size and remaining stable.
Personal cancer vaccine research concludes safety test
4. 3. 15 by Mark Parker