• The method works by targeting two different cell surface receptors of neurons that are responsible for triggering the specific chemical signals that control brain function and complex behaviors.
  • When this complex signaling system goes awry, the results can lead to a plethora of diseases, including schizophrenia, depression, Alzheimer’s Disease, Parkinson’s Disease, eating disorders, and epilepsy. Cell surface receptors also play roles in cancers, diabetes, digestive conditions, and other diseases. This new technique could be modified to study them, as well.
  • In one type of experiment, the NIH lab of Michael Krashes, PhD, was able to turn on and off voracious feeding behavior in mice. In another type of experiment, UNC researchers were able to turn on and off behaviors similar to those induced by drugs such as cocaine and amphetamines.

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