--- title: "Scientists Intrigued by Treatment That Put Every Single Patient’s Cancer Into Remission" description: "Doctors researching an experimental cancer treatment were shocked when every single patient in the small trial went into remission." date: "2022-06-06" modified: "2022-06-06" authors: - name: "Noor Al-Sibai" job_title: "Senior Staff Writer" link: "https://futurism.com/authors/nooralsibai" url: "https://futurism.com/neoscope/treatment-immunotherapy-cancer-remission" categories: - "Cancer" - "Health & Medicine" - "Medical" - "Treatments" tags: - "cancer" - "health" - "immunotherapy" - "studies" --- # Scientists Intrigued by Treatment That Put Every Single Patient’s Cancer Into Remission ![Doctors researching an experimental cancer treatment were shocked when every single patient in the small trial went into remission.]() *3d illustration of a cancer cell in the process of mitosis. \Image: Getty\* Doctors working on an experimental cancer treatment were heartened when every single patient in a small trial went into remission, their cancer becoming undetectable. Published [in the *New England Journal of Medicine*](), the paper that resulted from the trial details how all 12 patients who were given the experimental rectal cancer treatment went into remission without having chemotherapy. "I believe," Memorial Sloan Kettering (MSK) Cancer Center scientist Luis Diaz Jr [told the *New York Times*](), "this is the first time this has happened in the history of cancer." As [an MSK press release about the study describes](), study participants were treated to an incredible surprise when, after undergoing six months of the experimental immunotherapy treatment, they learned from their doctors that they were in remission. The first patient, named Sascha, was preparing to travel to New York to have radiation therapy when she got the call from her oncologist, Andrea Cercek, who said the patient was "stunned and ecstatic" at the news. "It’s incredibly rewarding," Cercek said in the press release, "to get these happy tears and happy emails from the patients in this study who finish treatment and realize, 'Oh my God, I get to keep all my normal body functions that I feared I might lose to radiation or surgery.'" The MSK doctors behind the study wanted to investigate whether immunotherapy alone could treat cancer, but they never expected it to work this well — and especially could not have foreseen that none of the 12 people in the initial trial had adverse reactions to the drug, known as dostarlimab. Dostarlimab is a checkpoint inhibitor, which "releases the brake on an immune cell, freeing it to recognize and attack cancer cells," according to the team. The finding is intriguing, but unlikely to represent a miracle cure. As the *NYT* cautioned, an average one in five people who take drugs like dostarlimab have an allergic reaction, and as many as 3 to 5 percent have severe reactions that include muscle weakness and trouble chewing and swallowing. Dr. Alan Venook, a University of California, San Francisco colorectal cancer specialist who wasn't involved in the study, told the *NYT* that the lack of side effects means that "either they did not treat enough patients or, somehow, these cancers are just plain different." Venook is not alone in his caution about the results. The trial was small, with only 12 participants, and has yet to be replicated. In an editorial [published in the ]()*[New England Journal of Medicine]()* in tandem with the initial study, Dr. Hanna Sanoff, a gastrointestinal medical oncologist at the University of North Carolina who was also not involved in the study, wrote that the "small but compelling" trial needs more time before doctors can fully understand the results. "Very little is known," Sanoff wrote, "about the duration of time needed to find out whether a clinical complete response to dostarlimab equates to cure." All the same, these unprecedented results are clearly pretty exciting for doctors and patients alike. **READ MORE:** [Rectal Cancer Disappears After Experimental Use of Immunotherapy]() \[Memorial Sloan Kettering Cancer Center\] **More immunotherapy:** [*Scientists Complete First Human Test of Vaccine Against Brain Cancer*]() ## Author At Futurism, I've often been drawn to unpacking the narratives that underlie technological, scientific and medical progress, with a special interest in areas of conflict and ambiguity that end up setting agendas and steering the fates of both elites and the hoi polloi. I'm a committed generalist, but I often find myself returning to work involving NASA and the private space sector, the effects of AI on media and society, and the mechanics of the pharmaceutical industry, with a specific focus on the spread of GLP-1 drugs like Ozempic and Wegovy. Prior to Futurism, I worked for publications ranging from Media Matters and Truthdig to Raw Story and Bustle. I'm also the author of "Myspace Scene Queens," a 2024 title in Instar Books' acclaimed "Remember the Internet" series. My work at Futurism has been cited by outlets including the New Yorker, Slate, Nieman Lab, the Verge, the MIT Technology Review, the Sunday Times, and the Daily Beast. I grew up in North Carolina, attended the University of North Carolina at Asheville, and now live in Brooklyn, New York. In my free time, I'm an avid reader and music fan; you can probably find me at a local poetry reading, concert, underground rave, or DJ set. I'm the proud parent of an ineffable orange cat named Mee-Mow. ### Author social links [Bluesky]()