--- title: "The Pig-Human Heart Transplant’s Secret Weapon? Cocaine" description: "To keep the gene-hacked pig heart beating during the historic operation earlier this month, surgeons used a drug cocktail that includes cocaine." date: "2022-01-24" modified: "2022-01-24" authors: - name: "Victor Tangermann" job_title: "Senior Editor" link: "https://futurism.com/authors/victor" url: "https://futurism.com/neoscope/pig-human-heart-transplant-cocaine" categories: - "Gene Editing" - "Genetics" - "Health & Medicine" tags: - "gene-editing" - "heart transplants" --- # The Pig-Human Heart Transplant’s Secret Weapon? Cocaine ![To keep the gene-hacked pig heart beating during the historic operation earlier this month, surgeons used a drug cocktail that includes cocaine.]() *\Image: Getty Images/Futurism\* US surgeons [successfully transplanted]() a genetically modified pig heart into a living human for the first time earlier this month, a groundbreaking moment in the history of medicine. And to keep the gene-hacked pig heart beating during the lengthy operation, surgeons used a drug cocktail with an eyebrow-raising ingredient: cocaine, [*Vice* reports](). The surgeons even had to get permission from the Drug Enforcement Administration to use the nose candy. "The cocaine name pops out because everybody thinks, 'Oh my God, what is cocaine doing in here?'" Muhammad Mohiuddin, director of cardiac xenotransplantation at at the University of Maryland Medical Center, told *Vice*. Counterintuitively, the drug was injected into the heart to prolong its longevity. "When we were not using this solution, we were getting failures within 48 hours," the surgeon explained. "But when we started using this and infusing the heart with this solution, the heart became well preserved and started beating very well." The cocktail, developed by Swedish pharmaceutical XVIVO, includes a number of other ingredients including cortisol and adrenaline. Scientists still don't know why exactly cocaine is an effective way to preserve hearts — but one thing is for certain: without drugs, the heart would've likely been rejected by its recipient's body. "It’s like a transplant from human to human, where you still have to use drugs but you know you can control it," Mohiuddin told *Vice*. "If we had not done that, the rejection happens within minutes and the organ is useless." **READ MORE:** [The Muslim Doctor Behind the First Cocaine-laced Pig-to-Human Heart Transplant]() \[*Vice*\] **More on the transplant:** *[Doctors Transplant Gene-Hacked Pig Heart Into Living Human]()* ## Author I've been at Futurism since 2017, where my role has evolved to encompass design, writing, and increasingly editing. I've always been fascinated by space exploration and advanced transportation, which I've leaned into by interviewing luminaries in those fields while closely following the dimensions of policy and regulation that allow next-generation projects to succeed -- or, sometimes, to fail. I'm also keenly interested in the effects of generative AI on society, policies, and democratic institutions, as well as clean energy, physics and biology, and the vagaries of tech leadership. My work for Futurism has been cited by publications including Ars Technica, Gizmodo, PC Magazine, Jalopnik, Fox News, and the New York Post. I spent my childhood living in locations including Manila, the Philippines, and Geneva, Switzerland, attended McGill University, and now live in Toronto, Canada. Before Futurism I worked at AskMen and a small photography studio. In my free time, I'm an avid gardener, foodie, and craft beer lover, as well as a maker of artisanal hot pepper sauces. I have a magnificent dog named Freida. ### Author social links [Bluesky]()