- Harmful bacteria have evolved some ingenious mechanisms to resist antibiotics. One of those is the drug efflux pump - proteins that stand guard along bacterial cell membranes, identifying antibacterial agents that pass through the membrane and swiftly ejecting them from the cell.
- The new approach makes use of molecular fragments administered alongside antimicrobial agents. The efflux pumps are kept busy pumping out the fragments while the antimicrobial agents are able to stay inside the cell.
- The strategy could also be applied in the treatment of cancer. Some cancers do not respond to drugs because cancerous cells have efflux pumps.
Molecular Decoys Help Overcome Drug Resistance
12. 13. 14 by Radu Serban