• The CRISPR-Cas system has been previously used to insert a foreign DNA sequence into a targeted genomic site in mammalian cells via a process of recombination. Here it was showed that the insertion could be performed using a simplified end joining process.
  • The methods used may help investigators genetically engineer cells to produce high levels of certain proteins—for example by placing the DNA sequence of a particular protein at the site of a highly active gene.
  • This is useful because it speeds up the discovery and application of the building blocks of genetic engineering. Similar methods are available in simpler organisms already, but mammalian cells are a more stable environment.

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