In BriefA team of researchers from Harvard and eGenesis have genetically engineered pigs, removing viruses to make transplanting their organs into humans safer. This could be a game changing development for the future of organ transplants.
Researchers have made a significant breakthrough in the area of organ transplants, and it brings us remarkably close to being able to safely transplant organs from other species into humans. In this latest work, scientists are working specifically with pig organs.
Notably, teams have been working on interspecies transplants for decades. One of the concerns that halted the previous studies was the 1998 discovery that retroviruses were hiding within pig DNA, which could possibly pose a threat to human recipients.
To combat this threat, a team from Harvard University and a private company, eGenesis, just created gene-edited pig clones that are completely free of the aforementioned retroviruses. Now, without the threat of these hidden diseases, it may be possible to safely transplant pig livers, hearts, and other organs. This adds to the growing number of transplants that are already in relatively widespread use in medicine (heart valves, skin grafts for burn patients, etc.).
Ultimately, these genetically altered pigs could be raised specifically for the harvesting of organs for transplant.
According to Dr. David Klassen, Chief Medical Officer at the United Network for Organ Sharing, last year saw 33,600 organ transplants, with another 116,800 people listed on various lists waiting for sutiable organs. If the research proves sound, Dr. Klassen believes this “…could be a real game changer.”