- The study relies on the use of phages, which transfer “edited” DNA into resistant bacteria to kill off resistant strains and make others more sensitive to antibiotics. The system, if ultimately applied to pathogens on hospital surfaces or medical personnel’s hands, could turn the tide on untreatable, often lethal bacterial infections.
- This approach combines CRISPR-Cas delivery with lytic phage selection of antibiotic-sensitized bacteria. The strategy may reduce the prevalence of antibiotic-resistant bacteria in treated surfaces and on skin of medical personnel, as it uses phages in a unique way that overcomes many of the hurdles encountered by phage therapy.
- Dr. Qimron and his team are now set to apply the CRISPR/phage system on Pseudomonas aeruginosa, one of the world’s most prevalent antibiotic-resistant pathogens involved in hospital-acquired infections, and to test whether bacterial sensitization works in a more complex microbial environment: the mouse cage.
CRISPR-Cas Technique Reverses Antibiotic Resistance in Bacteria
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