•  In 2008 a group led by Floyd Romesberg built two bases and showed that, just like DNA, natural enzymes could be used to replicate them. What we know about normal DNA is you have runs of the same base, AAAA or TTTT. Because of the way they are joined together Romesberg's bases can't form such long runs.
  • Now Georgiadis and Benner have shown that their Z and P bases can form these runs, behaving just like natural DNA. Using X-ray crystallography they found that the bases could incorporate themselves into strands of both natural and unnatural bases that included runs of Z and P up to six bases long.
  • The researchers also showed that the strands took on the same two forms that normal DNA uses inside cells: the familiar helical structure, called the "B" form, and a wider "A" form that DNA adopts when it is binding with a protein.

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